HPE ProLiant DL380 Gen10+ 2HE Xeon-S 4314 16-Core 2.4GHz 1x32GB-R 8xSFF Hot Plug NC MR416i-p 800W Server

Do your servers need increased performance in storage, compute, or expansion?The HPE ProLiant DL380 Gen10 Plus server is adaptable for diverse workloads and environments, providing you with the right balance of expandability and scalability. Designed for supreme versatility and resiliency, this 2U/2P platform is capable for deployment in multiple environments, built with a quality processor. Equipped with PCIe capabilities, the HPE ProLiant DL380 Gen10 Plus server offers improved data transfer rates and higher networking speeds.




36 Months On-Site Warranty


No optical drive

Product Form Factor

Rack-mountable – 2U

Server Scalability


Hot-Swap Bays Qty



Region: Worldwide


Intel Xeon Silver 4314

Clock Speed

2.4 GHz

Max Turbo Speed

3.4 GHz

Number of Cores




Max CPU Qty


CPU Upgradability


Chipset Type

Intel C621A

Installed Size

32 GB / 2 TB (max)

Cache Per Processor

24 MB



Effective Memory Speed

2933 MHz

Rated Memory Speed

3200 MHz

Form Factor

DIMM 288-pin


1 (total) / 1 (free) x PCIe 4.0 x16 – full-length, full-height

1 (total) / 1 (free) x PCIe 4.0 x16 – half-length, full-height (x8 mode)

1 (total) / 1 (free) x PCIe 4.0 x16 – full-length, full-height (x8 mode)


Registered, 8-channel memory architecture, HPE SmartMemory, slots 17 – 32 are available in two-processor configuration only

Configuration Features

1 x 32 GB

RAM Supported

8 TB Load-Reduced

2 TB registered

8 TB – HPE Persistent Memory – Optane DC Persistent

Buffer Size

4 GB

Monitor Type


Video Memory

16 MB

Video Interfaces


Interface (Bus) Type

Open Compute Project mezzanine (OCP) 3.0

Ethernet Ports

2 x 10 Gigabit Ethernet

Ethernet Controller

Broadcom BCM57412

Remote Management Controller

Integrated Lights-Out 5


8 (total) / 8 (free) x hot-swap 2.5" SFF


1 x HPE iLO – RJ-45

3 x USB 3.0 (1 front, 2 rear)

1 x HPE iLO (service port)

2 x LAN (10Gigabit Ethernet) – SFP+

1 x VGA

Included Accessories

CPU standard heatsink, HPE Easy Install Rails with CMA, 6 maximum performance fans

Compliant Standards

AES, FIPS 140-2, WEEE, Triple DES, TLS v1.2, ASHRAE Class A4, ASHRAE Class A3, Redfish API, UEFI, ACPI 6.3, SMBIOS 3.2

Device Type

Power supply – hot-plug

Power Redundancy


Power Redundancy Scheme

1+1 (with optional power supply)

Installed Qty


Max Supported Qty


Voltage Required

AC 120/230 V (50/60 Hz)

Power Provided

800 Watt

OS Provided

No operating system

Service & Support

Limited warranty – parts and labour – 3 years – on-site – response time: next business day


44.54 cm


71 cm


8.75 cm

Min Operating Temperature

10 °C

Max Operating Temperature

35 °C

Humidity Range Operating

8 – 90% (non-condensing)

  • The HPE ProLiant DL380 Gen10 Plus server is built with foundational intelligence to enhance workload performance, placement, and efficiency, delivering better outcomes faster. It provides real-time operational feedback on server performance and recommendations for fine-tuning BIOS settings to customize for your business needs.
  • The HPE ProLiant DL380 Gen10 Plus server provides an enhanced, holistic, 360-degree view to security that begins in the manufacturing supply chain and concludes with a safeguarded, end-of-life decommissioning. HPE ProLiant security begins with the corruption-free manufacture of the server and auditing the integrity of every component – hardware and firmware – to provide verification that the server begins its lifecycle uncompromised through the supply chain. HPE ProLiant servers provide rapid detection of a security-compromised server, even to the point of not allowing it to boot, verify containment of malicious code, and protect healthy servers. HPE ProLiant servers provide automated recovery from a security event, including restoration of validated firmware, and facilitating recovery of operating system, application and data connections, providing the fastest path to bring a server back online and into normal operations. When it’s time to retire or repurpose an HPE ProLiant server, one-button secure erase speeds and simplifies the complete removal of passwords, configuration settings and data, preventing inadvertent access to previously secured information.
  • The HPE ProLiant DL380 Gen10 Plus server simplifies and automates management tasks, establishing a solid foundation for an open, hybrid cloud platform enabled by composability. Embedded in HPE servers, HPE Integrated Lights-Out (iLO) is an exclusive core intelligence that monitors server status, providing the means for reporting, ongoing management, service alerting, and local or remote management to quickly identify and resolve issues. Automation and software defined control reduces time spent on provisioning and maintenance, as well as reduces deployment times from weeks to mere days. HPE InfoSight for Servers continually analyzes server infrastructure and applies real-world examples of hundreds of thousands of servers to predict and prevent problems before they can adversely affect business operations.